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The Health Technology Assessment Approach of The Economic Value of Diagnostic Test: A Literature Review

Author

Listed:
  • Bardey, David

    (Universidad de los Andes)

  • De Donder , Philippe

    (TSE - CNRS)

  • Zaporozhets , Vera

    (TSE - INRAe)

Abstract

We review the medico-economic literature assessing the economic value of diagnostic tests. We first present the health technology assessment methods, as applied to generic health interventions. We then define our object of study, diagnostic and prognostic tests, and relate them to various definitions of personalized medicine. We then review the empirical assessments of diagnostic tests related to personalized medicine and of companion tests. We summarize systematic reviews which are not performing quantitative meta-analyses, but rather provide a descriptive synthesis of the results reviewed. We find no evidence that such tests perform better than more traditional approaches, such as pharmaceutical interventions. At the same time, there is a lot of heterogeneity in the cost per QALY (Quality-Adjusted Life Year) gained, so that some genetic testing procedures may perform better than non-genetic ones. Finally, we focus on imperfect tests and show how to optimize, from an economic perspective, their accuracy levels, and how to take accuracy levels into considerations when assessing their economic value.

Suggested Citation

  • Bardey, David & De Donder , Philippe & Zaporozhets , Vera, 2024. "The Health Technology Assessment Approach of The Economic Value of Diagnostic Test: A Literature Review," Documentos CEDE 21041, Universidad de los Andes, Facultad de Economía, CEDE.
    • Handle: RePEc:col:000089:021041
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    File URL: https://repositorio.uniandes.edu.co/bitstreams/handle/1992/74009/dcede2024-06.pdf
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    More about this item

    Keywords

    genetic tests; companion tests; cost-benefit analysis (CBA); cost-effectiveness analysis (CEA); cost-utility analysis (CUA); and cost-minimization analysis (CMA); personalized medicine; Receiver-Operator (ROC) curve; Incremental cost-effectiveness ration (ICER).;
    All these keywords.

    JEL classification:

    • H51 - Public Economics - - National Government Expenditures and Related Policies - - - Government Expenditures and Health
    • I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health
    • J17 - Labor and Demographic Economics - - Demographic Economics - - - Value of Life; Foregone Income

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